San Rafael is one of the departments of Mendoza Province, Argentina. The seat of the department is in the city of San Rafael.
- Geographical location: 34° 15´ to 36° southern latitude and 70° 10´ to 66° 55´ eastern longitude.
- Area: 31,235 km² (20.82% of the provincial area)
- Extension: 204 km from north to south. 298 km from east to west
- Altitude: 750 m above sea level.
The department is subdivided in 18 districts: Ciudad, El Cerrito, Cuadro Nacional, Las Malvinas District, El Sosneado (added in 2005, it used to belong to Cuadro Benegas, but then it was added as a district), Las Paredes, La Llave, Cuadro Benegas, Cuadro Nacional, Cañada Seca, Goudge, Jaime Prats, Monte Comán, Rama Caída, Real del Padre, Punta del Agua, Villa Atuel and Villa 25 de Mayo.